Targeting the Imbalanced Immune Response in COVID-19

Too much histamine or prostaglandin D2 signaling or too little interferon signaling lead to increased risk for severe COVID-19.

Immune system issues associated with risk for severe COVID-19. Interferons are key antiviral proteins. Prostaglandin D2, prostaglandin E2, and thromboxane A2 are bioactive lipids produced from arachidonic acid by cyclo-oxygenase enzymes. Histamine is a biogenic amine. [Credit: Nancy R. Gough, BioSerendipity, LLC]

Ineffective interferon response

Hyperactive mast cell response

Altered eicosanoid response

Conclusion

Therapeutic options to prevent the development of severe COVID-19. [Credit Nancy R. Gough, BioSerendipity, LLC]

References

Also of interest

Scientist, editor, and writer with a PhD in Pharmacology

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