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Lyme disease word cloud. From https://www.datadriveninvestor.com/2020/08/21/pfizer-and-valneva-join-forces-on-lyme-disease-vaccine/.

Pfizer and Valneva Join Forces on Lyme Disease Vaccine

The engineered protein vaccine VLA15 induces multiple antibodies in a Phase II trial and has the potential to provide protection against the different bacteria that cause Lyme disease in North America and Europe.

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Diagram of the VLA vaccine strategy. The vaccine has 3 engineered proteins. Each contains 2 forms of OspA from different Borrelia bacterial serotypes and a lipid modification to enhance immunogenicity. The OspA proteins are shown as octagons and the antibodies induced by the vaccine as the Y-shapes. The linker connecting the two OspA proteins is shown as a gray line and the lipid is represented by wavy lines. [Credit: Nancy R. Gough, Ph.D. BioSerendipity, LLC]

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