I agree. The evidence in favor of using hydroxychloroquine is mostly from small studies in humans or cell culture. It is true that lysosomes are inhibited by these drugs. Whether the virus proteins are degraded by autophagy is unknown. They could also be degraded by proteasomal proteins, if tagged by ubiquitin, or cytosolic enzymes, such as caspases. It may be that at very early exposure inhibition of viral entry benefits and that later once a person has a full infection, then inhibition of lysosomes is detrimental. Clinical trials will sort out the right timing of treatments, such as prophylactic use of hydroxychloroquine in people who have been exposed to the virus. https://clinicaltrials.gov/ct2/show/NCT04328961

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