Mutations in genes in interferon signaling and autoantibodies targeting interferon explain ~14% of severe COVID-19 cases. Image shows DNA, interferon, and antibodies. [Credit: Nancy R. Gough, BioSerendipity, LLC]

Gene Mutations and Autoantibodies in Severe COVID-19

Genetic variations and autoantibodies that compromise interferon signaling explain ~14% of severe COVID-19 cases.

As researchers evaluate patients that develop severe COVID-19, the disease caused by the coronavirus SARS-CoV2, they are discovering answers to why some people become so critically ill…